-
Forum
-
Supplementarium
-
Healing
-
Osteoarthritis
-
FGF-18 (Sprifermin)
-
FGF-18 stimulates intestinal proliferation
FGF-18 stimulates intestinal proliferation
Less
More
-
Posts: 213
-
Karma: 4
-
Thank you received: 0
-
-
-
-
8 years 8 months ago #4931
by admin
FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation
To examine its biological activity in vivo, rMuFGF-18 was injected into normal mice and ectopically overexpressed in transgenic mice by using a liver-specific promoter. Injection of rMuFGF-18 induced proliferation in a wide variety of tissues, including tissues of both epithelial and mesenchymal origin. The two tissues which appeared to be the primary targets of FGF-18 were the liver and small intestine, both of which exhibited histologic evidence of proliferation and showed significant gains in organ weight following 7 (sometimes 3) days of FGF-18 treatment. Transgenic mice that overexpressed FGF-18 in the liver also exhibited an increase in liver weight and hepatocellular proliferation. These results suggest that FGF-18 is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine.
This had me a little worried until I read the full text:
Treatments consisted of intraperitoneal injections with either 5 mg of rMuFGF-18 or vehicle per kg.
So we're talking about injection into an area that will likely cause a more systemic reaction, and a dose that is orders of magnitude higher than what is used to regenerate cartilage in knees, for instance (where it is injected IA).
Not too much of a cause for concern IMO.
Please Log in to join the conversation.
Less
More
-
Posts: 10
-
Karma: 2
-
Thank you received: 0
-
-
8 years 8 months ago #4932
by repellent
Yes I agree this is systemic
Please Log in to join the conversation.
-
Forum
-
Supplementarium
-
Healing
-
Osteoarthritis
-
FGF-18 (Sprifermin)
-
FGF-18 stimulates intestinal proliferation
Time to create page: 0.084 seconds