Like other members of the bone morphogenetic protein family of proteins, BMP-7 plays a key role in the transformation of mesenchymal cells into bone and cartilage

FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening of cartilage in a murine model of osteoarthritis, and the recombinant version of it (sprifermin) will soon enter trials as a potential treatment for osteoarthritis

BPC-157, a pentadecapeptide derived from human gastric juice, has been
demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells into chondrocytes

TD-198946 is a novel disease-modifying osteoarthritis drug candidate targeting Runx1