IGF1 vs IGF1 LR3

repellent
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8 years 8 months ago #4910 by repellent

IGF1 vs IGF1 LR3 was created by repellent

IGF1 has been shown to be anabolic to cartilage in the animal model of OA, I understand IGF1-LR3 has more potency has anyone found any studies using IGF1-LR3 for cartilage regrowth or have any anecdotal experience?

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8 years 8 months ago #4913 by admin

Replied by admin on topic IGF1 vs IGF1 LR3

Is this the study you're referring to?

Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate

Do you know what the half-life of HB-IGF-1 is? This abstract mentions the half-life of IGF-1 being 8-16 hours in vivo.

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8 years 8 months ago #4918 by repellent

Replied by repellent on topic IGF1 vs IGF1 LR3

yes that's correct, you note that "IGF-1 directly to the joint through fibrin constructs (18–20) have been promising, but rapid clearance of IGF-1 from the joint has prevented intra-articular injections of IGF-1 without a carrier from being effective (9), and has been a limiting factor in delivery methods proposed to date," also IGF1-LR3 has half life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).

Not sure what implications this has yet

The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.

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8 years 8 months ago #4919 by repellent

Replied by repellent on topic IGF1 vs IGF1 LR3

this explains the benefit of avoiding the IGFBP

www.ncbi.nlm.nih.gov/pubmed/11014363

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8 years 8 months ago #4924 by admin

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repellent wrote: this explains the benefit of avoiding the IGFBP

www.ncbi.nlm.nih.gov/pubmed/11014363

CONCLUSION: These results demonstrate a significant age-related decline in the chondrocyte response to IGF-1. The finding that increasing OA score was associated with a reduced response to intact IGF-1 but not des(1-3) IGF-1 suggests a role of increased production of inhibitory IGFBP in OA. Since the cells from older animals had a reduced response to both forms of IGF-1, the mechanism of the reduced response with age cannot be attributed to changes in IGFBP. Age-related changes in IGF receptors or, more likely, age-related alterations in intracellular signal transduction may also be involved.

I'm trying to get my head around the meaning of this:

RESULTS: ... There was a significantly reduced response to des(1-3) IGF-1 with increasing age, but no effect of OA score on response to des(1-3) IGF-1.

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8 years 8 months ago #4926 by repellent

Replied by repellent on topic IGF1 vs IGF1 LR3

I think its saying that as we age we have reduced response to dea(1-3), but this doesn't change the fact that we have increased response to des(1-3) IGF-1 in the OA joint, it summarizes with "the mechanism of the reduced response with age cannot be attributed to changes in IGFBP. Age-related changes in IGF receptors or, more likely, age-related alterations in intracellular signal transduction may also be involved."

So my theory is ( and it is just a theory ) that des(1-3)IGF-1 is better for joints than IGF-1; this may also be the case with LR3-IGF1. But Des(1-3) is readily available

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